Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2189751..2190313 Replicon chromosome
Accession NZ_CP117628
Organism Escherichia albertii strain BIA_22

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag PS041_RS10980 Protein ID WP_000605679.1
Coordinates 2190035..2190313 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS041_RS10975 Protein ID WP_000781370.1
Coordinates 2189751..2190035 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS041_RS10960 (2184933) 2184933..2187980 + 3048 WP_273825405.1 formate dehydrogenase-N subunit alpha -
PS041_RS10965 (2187993) 2187993..2188877 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS041_RS10970 (2188870) 2188870..2189523 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS041_RS10975 (2189751) 2189751..2190035 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS041_RS10980 (2190035) 2190035..2190313 - 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS041_RS10985 (2190499) 2190499..2191509 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS041_RS10990 (2191644) 2191644..2193341 - 1698 WP_059259313.1 malate dehydrogenase -
PS041_RS10995 (2193498) 2193498..2193635 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS041_RS11000 (2193893) 2193893..2194324 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T271766 WP_000605679.1 NZ_CP117628:c2190313-2190035 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271766 WP_000781370.1 NZ_CP117628:c2190035-2189751 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References