Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4383804..4384516 Replicon chromosome
Accession NZ_CP117620
Organism Escherichia albertii strain BIA_24

Toxin (Protein)


Gene name higB Uniprot ID A0A8D9ULK1
Locus tag PS039_RS21355 Protein ID WP_059257620.1
Coordinates 4383804..4384106 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS039_RS21360 Protein ID WP_000806446.1
Coordinates 4384178..4384516 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS039_RS21330 (4380467) 4380467..4381309 + 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS039_RS21335 (4381381) 4381381..4382733 + 1353 WP_059225142.1 glutathione-disulfide reductase -
PS039_RS21340 (4382787) 4382787..4382870 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS039_RS21345 (4382898) 4382898..4383071 + 174 WP_059225143.1 hypothetical protein -
PS039_RS21350 (4383161) 4383161..4383640 - 480 WP_273809833.1 hypothetical protein -
PS039_RS21355 (4383804) 4383804..4384106 + 303 WP_059257620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS039_RS21360 (4384178) 4384178..4384516 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS039_RS21365 (4384573) 4384573..4384752 + 180 WP_002460167.1 hypothetical protein -
PS039_RS21370 (4385088) 4385088..4385654 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS039_RS21375 (4385801) 4385801..4386331 + 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS039_RS21380 (4386403) 4386403..4387431 - 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS039_RS21385 (4387480) 4387480..4389462 - 1983 WP_000089601.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11843.53 Da        Isoelectric Point: 9.8664

>T271748 WP_059257620.1 NZ_CP117620:4383804-4384106 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWANGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271748 WP_000806446.1 NZ_CP117620:4384178-4384516 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References