Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3716346..3717040 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PS046_RS18140 Protein ID WP_001263500.1
Coordinates 3716346..3716744 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PS046_RS18145 Protein ID WP_000554758.1
Coordinates 3716747..3717040 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS18110 (3711480) 3711480..3712937 + 1458 WP_001292996.1 cytosol nonspecific dipeptidase -
PS046_RS18115 (3712985) 3712985..3713227 + 243 WP_001029361.1 hypothetical protein -
PS046_RS18120 (3713244) 3713244..3713753 - 510 WP_001361775.1 metal-dependent hydrolase -
PS046_RS18125 (3713815) 3713815..3714429 - 615 WP_095573646.1 peptide chain release factor H -
PS046_RS18130 (3714426) 3714426..3715565 - 1140 WP_233929378.1 RNA ligase RtcB family protein -
PS046_RS18135 (3715884) 3715884..3716336 - 453 WP_273812271.1 GNAT family N-acetyltransferase -
PS046_RS18140 (3716346) 3716346..3716744 - 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PS046_RS18145 (3716747) 3716747..3717040 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PS046_RS18150 (3717092) 3717092..3718147 - 1056 WP_059217800.1 DNA polymerase IV -
PS046_RS18155 (3718277) 3718277..3719044 - 768 WP_072243690.1 putative lateral flagellar export/assembly protein LafU -
PS046_RS18160 (3719016) 3719016..3720728 + 1713 Protein_3553 flagellar biosynthesis protein FlhA -
PS046_RS18165 (3720844) 3720844..3721341 - 498 WP_095573642.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T271717 WP_001263500.1 NZ_CP117615:c3716744-3716346 [Escherichia albertii]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT271717 WP_000554758.1 NZ_CP117615:c3717040-3716747 [Escherichia albertii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References