Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2442327..2442889 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS046_RS11945 Protein ID WP_059278671.1
Coordinates 2442327..2442605 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS046_RS11950 Protein ID WP_000781370.1
Coordinates 2442605..2442889 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS11925 (2438316) 2438316..2438747 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS046_RS11930 (2439005) 2439005..2439142 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS046_RS11935 (2439299) 2439299..2440996 + 1698 WP_000433442.1 malate dehydrogenase -
PS046_RS11940 (2441131) 2441131..2442141 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS046_RS11945 (2442327) 2442327..2442605 + 279 WP_059278671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS046_RS11950 (2442605) 2442605..2442889 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS046_RS11955 (2443118) 2443118..2443771 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS046_RS11960 (2443764) 2443764..2444648 - 885 WP_059268408.1 formate dehydrogenase N subunit beta -
PS046_RS11965 (2444661) 2444661..2447708 - 3048 WP_077871680.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10480.14 Da        Isoelectric Point: 8.9374

>T271711 WP_059278671.1 NZ_CP117615:2442327-2442605 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYKDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271711 WP_000781370.1 NZ_CP117615:2442605-2442889 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References