Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1120277..1120521 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag PS046_RS05380 Protein ID WP_000956458.1
Coordinates 1120369..1120521 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1120277..1120324 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS05365 1115680..1117479 + 1800 WP_095574182.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
PS046_RS05370 1117479..1119191 + 1713 WP_059221001.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
PS046_RS05375 1119371..1120105 + 735 WP_001125132.1 phosphoadenosine phosphosulfate reductase -
- 1120277..1120324 - 48 - - Antitoxin
PS046_RS05380 1120369..1120521 + 153 WP_000956458.1 Hok/Gef family protein Toxin
PS046_RS05385 1120714..1121826 - 1113 WP_095574181.1 IS4-like element IS421 family transposase -
PS046_RS05390 1122079..1124736 + 2658 WP_059221338.1 CRISPR-associated helicase/endonuclease Cas3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T271705 WP_000956458.1 NZ_CP117615:1120369-1120521 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 48 bp

>AT271705 NZ_CP117615:c1120324-1120277 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References