Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 250100..250812 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS046_RS01150 Protein ID WP_000162413.1
Coordinates 250510..250812 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS046_RS01145 Protein ID WP_000806446.1
Coordinates 250100..250438 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS01120 (245732) 245732..246760 + 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS046_RS01125 (246832) 246832..247362 - 531 WP_059220985.1 LuxR C-terminal-related transcriptional regulator -
PS046_RS01130 (247509) 247509..248075 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS046_RS01135 (248281) 248281..249417 - 1137 WP_095574327.1 pentapeptide repeat-containing protein -
PS046_RS01140 (249864) 249864..250043 - 180 WP_002460167.1 hypothetical protein -
PS046_RS01145 (250100) 250100..250438 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS046_RS01150 (250510) 250510..250812 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS046_RS01155 (250976) 250976..251470 + 495 WP_095574326.1 hypothetical protein -
PS046_RS01160 (251544) 251544..251717 - 174 WP_059235695.1 hypothetical protein -
PS046_RS01165 (251745) 251745..251828 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS046_RS01170 (251882) 251882..253234 - 1353 WP_054410173.1 glutathione-disulfide reductase -
PS046_RS01175 (253306) 253306..254148 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271701 WP_000162413.1 NZ_CP117615:c250812-250510 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271701 WP_000806446.1 NZ_CP117615:c250438-250100 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References