Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 173177..173434 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag PS046_RS00805 Protein ID WP_001135738.1
Coordinates 173282..173434 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 173177..173225 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS00785 168407..169402 - 996 Protein_155 acyltransferase -
PS046_RS00790 169575..169874 + 300 WP_000979961.1 YsaB family lipoprotein -
PS046_RS00795 169970..170881 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
PS046_RS00800 170891..172960 + 2070 WP_095574339.1 glycine--tRNA ligase subunit beta -
- 173177..173225 - 49 - - Antitoxin
PS046_RS00805 173282..173434 + 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
PS046_RS00810 173411..173482 - 72 WP_212734940.1 hypothetical protein -
PS046_RS00815 173622..173834 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PS046_RS00820 174117..174407 - 291 WP_059221281.1 HTH-type transcriptional regulator -
PS046_RS00825 174830..175540 + 711 WP_002460072.1 DUF3053 domain-containing protein -
PS046_RS00830 175593..176567 - 975 WP_059221283.1 glyoxylate/hydroxypyruvate reductase GhrB -
PS046_RS00835 176671..177330 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T271700 WP_001135738.1 NZ_CP117615:173282-173434 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

Antitoxin


Download         Length: 49 bp

>AT271700 NZ_CP117615:c173225-173177 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References