Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1096865..1097592 Replicon chromosome
Accession NZ_CP117609
Organism Escherichia albertii strain BIA_26

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag PS038_RS05245 Protein ID WP_000547563.1
Coordinates 1096865..1097176 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS038_RS05250 Protein ID WP_000126297.1
Coordinates 1097173..1097592 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS038_RS05215 (1092007) 1092007..1093716 + 1710 WP_025238503.1 formate hydrogenlyase subunit HycE -
PS038_RS05220 (1093726) 1093726..1094268 + 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
PS038_RS05225 (1094268) 1094268..1095035 + 768 WP_000067396.1 formate hydrogenlyase subunit HycG -
PS038_RS05230 (1095032) 1095032..1095442 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
PS038_RS05235 (1095435) 1095435..1095905 + 471 WP_059219259.1 hydrogenase maturation peptidase HycI -
PS038_RS05240 (1095948) 1095948..1096703 + 756 WP_059219258.1 hypothetical protein -
PS038_RS05245 (1096865) 1096865..1097176 + 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
PS038_RS05250 (1097173) 1097173..1097592 + 420 WP_000126297.1 helix-turn-helix domain-containing protein Antitoxin
PS038_RS05255 (1097684) 1097684..1098112 - 429 WP_000536065.1 DUF4259 domain-containing protein -
PS038_RS05260 (1098534) 1098534..1099061 + 528 WP_001078777.1 electron transport protein HydN -
PS038_RS05265 (1099214) 1099214..1101466 + 2253 WP_273818247.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T271677 WP_000547563.1 NZ_CP117609:1096865-1097176 [Escherichia albertii]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15446.45 Da        Isoelectric Point: 4.4596

>AT271677 WP_000126297.1 NZ_CP117609:1097173-1097592 [Escherichia albertii]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References