Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 248408..249120 Replicon chromosome
Accession NZ_CP117609
Organism Escherichia albertii strain BIA_26

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS038_RS01115 Protein ID WP_000162413.1
Coordinates 248818..249120 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS038_RS01110 Protein ID WP_000806446.1
Coordinates 248408..248746 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS038_RS01085 (243509) 243509..245491 + 1983 WP_059215192.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS038_RS01090 (245540) 245540..246568 + 1029 WP_059218981.1 hematinate-forming heme oxygenase ChuS -
PS038_RS01095 (246640) 246640..247170 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS038_RS01100 (247317) 247317..247883 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS038_RS01105 (248172) 248172..248351 - 180 WP_059219034.1 hypothetical protein -
PS038_RS01110 (248408) 248408..248746 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS038_RS01115 (248818) 248818..249120 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS038_RS01120 (249284) 249284..249763 + 480 WP_000532312.1 hypothetical protein -
PS038_RS01125 (249853) 249853..250026 - 174 WP_044708027.1 hypothetical protein -
PS038_RS01130 (250054) 250054..250137 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS038_RS01135 (250191) 250191..251543 - 1353 WP_059218982.1 glutathione-disulfide reductase -
PS038_RS01140 (251615) 251615..252457 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271674 WP_000162413.1 NZ_CP117609:c249120-248818 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271674 WP_000806446.1 NZ_CP117609:c248746-248408 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References