Detailed information of TA system TA271659

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3499978..3500235
• Replicon: chromosome
• Accession: NZ_CP117606
• Organism: Escherichia albertii strain BIA_29

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: PS031_RS17120
• Protein ID: WP_001135738.1
• Coordinates: 3499978..3500130 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3500187..3500235 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PS031_RS17090	3496083..3496742	+	660	WP_000747625.1	OmpA family lipoprotein	-
PS031_RS17095	3496846..3497820	+	975	WP_000804993.1	glyoxylate/hydroxypyruvate reductase GhrB	-
PS031_RS17100	3497873..3498583	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
PS031_RS17105	3499006..3499296	+	291	WP_000455794.1	HTH-type transcriptional regulator	-
PS031_RS17110	3499579..3499791	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
PS031_RS17115	3499930..3500001	+	72	WP_212743705.1	hypothetical protein	-
PS031_RS17120	3499978..3500130	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	3500187..3500235	+	49	-	-	Antitoxin
PS031_RS17125	3500452..3502521	-	2070	WP_001291807.1	glycine--tRNA ligase subunit beta	-
PS031_RS17130	3502531..3503442	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
PS031_RS17135	3503538..3503837	-	300	WP_204628985.1	YsaB family lipoprotein	-
PS031_RS17140	3504010..3505005	+	996	WP_273770034.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T271659 WP_001135738.1 NZ_CP117606:c3500130-3499978 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 49 bp

>AT271659 NZ_CP117606:3500187-3500235 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin