Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3418306..3419018 Replicon chromosome
Accession NZ_CP117606
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS031_RS16755 Protein ID WP_000162413.1
Coordinates 3418306..3418608 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS031_RS16760 Protein ID WP_000806446.1
Coordinates 3418680..3419018 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS16730 (3414969) 3414969..3415811 + 843 WP_010326142.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS031_RS16735 (3415883) 3415883..3417235 + 1353 WP_149541542.1 glutathione-disulfide reductase -
PS031_RS16740 (3417289) 3417289..3417372 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS031_RS16745 (3417400) 3417400..3417573 + 174 WP_187765834.1 hypothetical protein -
PS031_RS16750 (3417663) 3417663..3418142 - 480 WP_204628992.1 hypothetical protein -
PS031_RS16755 (3418306) 3418306..3418608 + 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS031_RS16760 (3418680) 3418680..3419018 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS031_RS16765 (3419109) 3419109..3419258 + 150 WP_233991781.1 hypothetical protein -
PS031_RS16770 (3419605) 3419605..3420171 + 567 WP_059216822.1 outer membrane lipoprotein Slp -
PS031_RS16775 (3420318) 3420318..3420848 + 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS031_RS16780 (3420920) 3420920..3421948 - 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS031_RS16785 (3421997) 3421997..3423979 - 1983 WP_103054026.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271658 WP_000162413.1 NZ_CP117606:3418306-3418608 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271658 WP_000806446.1 NZ_CP117606:3418680-3419018 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References