Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3073077..3073876 Replicon chromosome
Accession NZ_CP117606
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PS031_RS14955 Protein ID WP_000347251.1
Coordinates 3073412..3073876 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS031_RS14950 Protein ID WP_001296435.1
Coordinates 3073077..3073412 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS14935 (3068866) 3068866..3069636 - 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -
PS031_RS14940 (3069652) 3069652..3070986 - 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
PS031_RS14945 (3071357) 3071357..3072928 + 1572 WP_273769546.1 galactarate dehydratase -
PS031_RS14950 (3073077) 3073077..3073412 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS031_RS14955 (3073412) 3073412..3073876 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS031_RS14960 (3073931) 3073931..3074740 - 810 WP_103053960.1 aga operon transcriptional regulator AgaR -
PS031_RS14965 (3074989) 3074989..3076269 + 1281 WP_059216469.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS031_RS14970 (3076292) 3076292..3076765 + 474 WP_059218168.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS031_RS14975 (3076776) 3076776..3077555 + 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS031_RS14980 (3077545) 3077545..3078423 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS031_RS14985 (3078441) 3078441..3078875 + 435 WP_000948821.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T271657 WP_000347251.1 NZ_CP117606:3073412-3073876 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271657 WP_001296435.1 NZ_CP117606:3073077-3073412 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References