Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3032309..3033036 Replicon chromosome
Accession NZ_CP117606
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PS031_RS14755 Protein ID WP_000550189.1
Coordinates 3032722..3033036 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS031_RS14750 Protein ID WP_000560272.1
Coordinates 3032309..3032725 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS14740 (3027624) 3027624..3029975 + 2352 WP_273769472.1 alpha-glucosidase -
PS031_RS14745 (3030201) 3030201..3032219 + 2019 WP_204629079.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PS031_RS14750 (3032309) 3032309..3032725 - 417 WP_000560272.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PS031_RS14755 (3032722) 3032722..3033036 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PS031_RS14760 (3033319) 3033319..3034455 - 1137 WP_059241776.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PS031_RS14765 (3034540) 3034540..3035043 + 504 WP_204629078.1 M48 family metallopeptidase -
PS031_RS14770 (3035120) 3035120..3035812 + 693 WP_204629077.1 vancomycin high temperature exclusion protein -
PS031_RS14775 (3035891) 3035891..3036877 + 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T271656 WP_000550189.1 NZ_CP117606:c3033036-3032722 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14993.40 Da        Isoelectric Point: 4.3697

>AT271656 WP_000560272.1 NZ_CP117606:c3032725-3032309 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References