Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 14656..15302 Replicon plasmid pEA32_4
Accession NZ_CP117604
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS047_RS25745 Protein ID WP_273824034.1
Coordinates 14955..15302 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS047_RS25740 Protein ID WP_001673379.1
Coordinates 14656..14955 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS25705 (PS047_25705) 10223..10762 - 540 WP_273824033.1 helix-turn-helix domain-containing protein -
PS047_RS25710 (PS047_25710) 11208..11399 + 192 WP_000183351.1 hypothetical protein -
PS047_RS25715 (PS047_25715) 11396..11743 + 348 Protein_20 ORF6N domain-containing protein -
PS047_RS25720 (PS047_25720) 11912..12538 + 627 WP_273824042.1 Rha family transcriptional regulator -
PS047_RS25725 (PS047_25725) 13354..13626 - 273 WP_000148348.1 helix-turn-helix domain-containing protein -
PS047_RS25730 (PS047_25730) 13690..14070 - 381 WP_000061763.1 hypothetical protein -
PS047_RS25735 (PS047_25735) 14338..14622 + 285 WP_033816863.1 hypothetical protein -
PS047_RS25740 (PS047_25740) 14656..14955 - 300 WP_001673379.1 XRE family transcriptional regulator Antitoxin
PS047_RS25745 (PS047_25745) 14955..15302 - 348 WP_273824034.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS047_RS25750 (PS047_25750) 15547..15810 - 264 WP_273824035.1 hypothetical protein -
PS047_RS25755 (PS047_25755) 15834..16121 - 288 WP_000356589.1 hypothetical protein -
PS047_RS25760 (PS047_25760) 16764..17744 - 981 WP_249415694.1 plasmid replication initiator RepA -
PS047_RS25765 (PS047_25765) 18137..18670 + 534 WP_273824036.1 DapH/DapD/GlmU-related protein -
PS047_RS25770 (PS047_25770) 18688..19830 + 1143 WP_273824037.1 lipopolysaccharide N-acetylglucosaminyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49535 49535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13530.45 Da        Isoelectric Point: 8.8413

>T271644 WP_273824034.1 NZ_CP117604:c15302-14955 [Escherichia albertii]
MWTVLFSQRFNDWLNEQEDALQEKVLADLKNLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYEKLVRIAEDEFAAHLNTLESK

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11069.90 Da        Isoelectric Point: 5.8899

>AT271644 WP_001673379.1 NZ_CP117604:c14955-14656 [Escherichia albertii]
MRTLDEVIASRSPESQARIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRVAFHV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References