Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 4075701..4076395 Replicon chromosome
Accession NZ_CP117600
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PS047_RS20140 Protein ID WP_001263500.1
Coordinates 4075997..4076395 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PS047_RS20135 Protein ID WP_000554758.1
Coordinates 4075701..4075994 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS20115 (4071400) 4071400..4071897 + 498 WP_059275984.1 transposase -
PS047_RS20120 (4072013) 4072013..4073725 - 1713 Protein_3919 flagellar biosynthesis protein FlhA -
PS047_RS20125 (4073697) 4073697..4074464 + 768 WP_072243690.1 putative lateral flagellar export/assembly protein LafU -
PS047_RS20130 (4074594) 4074594..4075649 + 1056 WP_059217800.1 DNA polymerase IV -
PS047_RS20135 (4075701) 4075701..4075994 + 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PS047_RS20140 (4075997) 4075997..4076395 + 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PS047_RS20145 (4076405) 4076405..4076857 + 453 WP_072243685.1 GNAT family N-acetyltransferase -
PS047_RS20150 (4076870) 4076870..4077469 + 600 WP_072249376.1 peptide chain release factor H -
PS047_RS20155 (4077485) 4077485..4077607 + 123 Protein_3926 metal-dependent hydrolase -
PS047_RS20160 (4077610) 4077610..4077852 - 243 WP_059222190.1 hypothetical protein -
PS047_RS20165 (4077911) 4077911..4079368 - 1458 WP_001292996.1 cytosol nonspecific dipeptidase -
PS047_RS20170 (4079629) 4079629..4080087 + 459 WP_273823547.1 xanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T271638 WP_001263500.1 NZ_CP117600:4075997-4076395 [Escherichia albertii]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT271638 WP_000554758.1 NZ_CP117600:4075701-4075994 [Escherichia albertii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References