Detailed information of TA system TA271636

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2906553..2906810
• Replicon: chromosome
• Accession: NZ_CP117600
• Organism: Escherichia albertii strain BIA_32

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: PS047_RS14655
• Protein ID: WP_001135738.1
• Coordinates: 2906553..2906705 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2906762..2906810 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PS047_RS14625	2902657..2903316	+	660	WP_000747625.1	OmpA family lipoprotein	-
PS047_RS14630	2903420..2904394	+	975	WP_059221283.1	glyoxylate/hydroxypyruvate reductase GhrB	-
PS047_RS14635	2904447..2905157	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
PS047_RS14640	2905580..2905870	+	291	WP_059221281.1	HTH-type transcriptional regulator	-
PS047_RS14645	2906153..2906365	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
PS047_RS14650	2906505..2906576	+	72	WP_212734940.1	hypothetical protein	-
PS047_RS14655	2906553..2906705	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2906762..2906810	+	49	-	-	Antitoxin
PS047_RS14660	2907027..2909096	-	2070	WP_059221279.1	glycine--tRNA ligase subunit beta	-
PS047_RS14665	2909106..2910017	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
PS047_RS14670	2910113..2910412	-	300	WP_000979961.1	YsaB family lipoprotein	-
PS047_RS14675	2910585..2911580	+	996	WP_059221277.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T271636 WP_001135738.1 NZ_CP117600:c2906705-2906553 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 49 bp

>AT271636 NZ_CP117600:2906762-2906810 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin