Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2832671..2833383 Replicon chromosome
Accession NZ_CP117600
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS047_RS14330 Protein ID WP_059220983.1
Coordinates 2832671..2832973 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS047_RS14335 Protein ID WP_000806446.1
Coordinates 2833045..2833383 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS14315 (2829534) 2829534..2830376 + 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS047_RS14320 (2830448) 2830448..2831800 + 1353 WP_054410173.1 glutathione-disulfide reductase -
PS047_RS14325 (2831854) 2831854..2831937 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS047_RS14330 (2832671) 2832671..2832973 + 303 WP_059220983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS047_RS14335 (2833045) 2833045..2833383 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS047_RS14340 (2833440) 2833440..2833619 + 180 WP_002460167.1 hypothetical protein -
PS047_RS14345 (2833956) 2833956..2834528 + 573 WP_273823453.1 outer membrane lipoprotein Slp -
PS047_RS14350 (2834670) 2834670..2835200 + 531 WP_059220985.1 LuxR C-terminal-related transcriptional regulator -
PS047_RS14355 (2835272) 2835272..2836300 - 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS047_RS14360 (2836349) 2836349..2838330 - 1982 Protein_2812 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11885.61 Da        Isoelectric Point: 9.8664

>T271635 WP_059220983.1 NZ_CP117600:2832671-2832973 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNDYSSIRVNNQYR
LIFKWVNGKAEDLYLAPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271635 WP_000806446.1 NZ_CP117600:2833045-2833383 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References