Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 614739..615301 Replicon chromosome
Accession NZ_CP117600
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS047_RS03135 Protein ID WP_059278671.1
Coordinates 615023..615301 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS047_RS03130 Protein ID WP_000781370.1
Coordinates 614739..615023 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS03115 (609920) 609920..612967 + 3048 WP_077871680.1 formate dehydrogenase-N subunit alpha -
PS047_RS03120 (612980) 612980..613864 + 885 WP_059221881.1 formate dehydrogenase N subunit beta -
PS047_RS03125 (613857) 613857..614510 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS047_RS03130 (614739) 614739..615023 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS047_RS03135 (615023) 615023..615301 - 279 WP_059278671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS047_RS03140 (615487) 615487..616497 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS047_RS03145 (616632) 616632..618329 - 1698 WP_000433442.1 malate dehydrogenase -
PS047_RS03150 (618486) 618486..618623 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS047_RS03155 (618881) 618881..619312 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10480.14 Da        Isoelectric Point: 8.9374

>T271624 WP_059278671.1 NZ_CP117600:c615301-615023 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYKDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271624 WP_000781370.1 NZ_CP117600:c615023-614739 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References