Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4529428..4530030 Replicon chromosome
Accession NZ_CP117595
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS050_RS21820 Protein ID WP_059256930.1
Coordinates 4529719..4530030 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS050_RS21815 Protein ID WP_273818942.1
Coordinates 4529428..4529718 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS21780 (4524842) 4524842..4525744 + 903 WP_000331386.1 formate dehydrogenase O subunit beta -
PS050_RS21785 (4525741) 4525741..4526376 + 636 WP_000829019.1 formate dehydrogenase cytochrome b556 subunit -
PS050_RS21790 (4526373) 4526373..4527302 + 930 WP_000027704.1 formate dehydrogenase accessory protein FdhE -
PS050_RS21795 (4527339) 4527339..4527698 - 360 Protein_4261 type II toxin-antitoxin system VapC family toxin -
PS050_RS21800 (4527698) 4527698..4527940 - 243 Protein_4262 ribbon-helix-helix domain-containing protein -
PS050_RS21805 (4528158) 4528158..4528376 - 219 WP_001251292.1 CopG family transcriptional regulator -
PS050_RS21810 (4528791) 4528791..4529069 - 279 WP_032278934.1 hypothetical protein -
PS050_RS21815 (4529428) 4529428..4529718 - 291 WP_273818942.1 helix-turn-helix domain-containing protein Antitoxin
PS050_RS21820 (4529719) 4529719..4530030 - 312 WP_059256930.1 hypothetical protein Toxin
PS050_RS21825 (4530259) 4530259..4531167 + 909 WP_137651699.1 alpha/beta hydrolase -
PS050_RS21830 (4531233) 4531233..4532174 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PS050_RS21835 (4532219) 4532219..4532656 - 438 WP_000560977.1 D-aminoacyl-tRNA deacylase -
PS050_RS21840 (4532653) 4532653..4533525 - 873 WP_000916663.1 virulence factor BrkB family protein -
PS050_RS21845 (4533519) 4533519..4534118 - 600 WP_002460585.1 glucose-1-phosphatase -
PS050_RS21850 (4534217) 4534217..4535002 - 786 WP_000059671.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12143.16 Da        Isoelectric Point: 9.5486

>T271611 WP_059256930.1 NZ_CP117595:c4530030-4529719 [Escherichia albertii]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIC
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10789.37 Da        Isoelectric Point: 10.5848

>AT271611 WP_273818942.1 NZ_CP117595:c4529718-4529428 [Escherichia albertii]
MDKALFERLTHSMAQMNEIIEGTLQPSRTFEVDAMKIKEIRRASGVSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References