Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1108356..1108602 Replicon chromosome
Accession NZ_CP117595
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag PS050_RS05365 Protein ID WP_000956458.1
Coordinates 1108450..1108602 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1108356..1108408 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS05350 1103760..1105559 + 1800 WP_161538532.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
PS050_RS05355 1105559..1107271 + 1713 WP_161538531.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
PS050_RS05360 1107451..1108185 + 735 WP_001125132.1 phosphoadenosine phosphosulfate reductase -
- 1108356..1108408 - 53 - - Antitoxin
PS050_RS05365 1108450..1108602 + 153 WP_000956458.1 Hok/Gef family protein Toxin
PS050_RS05370 1108795..1109907 - 1113 WP_273819074.1 IS4 family transposase -
PS050_RS05375 1110160..1112817 + 2658 WP_273819075.1 CRISPR-associated helicase Cas3' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T271598 WP_000956458.1 NZ_CP117595:1108450-1108602 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 53 bp

>AT271598 NZ_CP117595:c1108408-1108356 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References