Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 807643..808442 Replicon chromosome
Accession NZ_CP117595
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9C2I0
Locus tag PS050_RS03960 Protein ID WP_059227548.1
Coordinates 807643..808107 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS050_RS03965 Protein ID WP_001296435.1
Coordinates 808107..808442 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS03930 (802644) 802644..803078 - 435 WP_000948821.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PS050_RS03935 (803096) 803096..803974 - 879 WP_059256166.1 PTS N-acetylgalactosamine transporter subunit IID -
PS050_RS03940 (803964) 803964..804743 - 780 WP_141109251.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS050_RS03945 (804754) 804754..805227 - 474 WP_002461030.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS050_RS03950 (805250) 805250..806530 - 1281 WP_059216469.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS050_RS03955 (806779) 806779..807588 + 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
PS050_RS03960 (807643) 807643..808107 - 465 WP_059227548.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS050_RS03965 (808107) 808107..808442 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS050_RS03970 (808591) 808591..810162 - 1572 WP_273819048.1 galactarate dehydratase -
PS050_RS03975 (810532) 810532..811866 + 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
PS050_RS03980 (811882) 811882..812652 + 771 WP_001063508.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17819.26 Da        Isoelectric Point: 9.7301

>T271596 WP_059227548.1 NZ_CP117595:c808107-807643 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271596 WP_001296435.1 NZ_CP117595:c808442-808107 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References