Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3693135..3693829 Replicon chromosome
Accession NZ_CP117590
Organism Escherichia albertii strain BIA_36

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PS051_RS18445 Protein ID WP_001263500.1
Coordinates 3693135..3693533 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PS051_RS18450 Protein ID WP_000554758.1
Coordinates 3693536..3693829 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS051_RS18415 (3689443) 3689443..3689901 - 459 WP_001291989.1 xanthine phosphoribosyltransferase -
PS051_RS18420 (3690162) 3690162..3691619 + 1458 WP_001292996.1 cytosol nonspecific dipeptidase -
PS051_RS18425 (3691678) 3691678..3691920 + 243 WP_059222190.1 hypothetical protein -
PS051_RS18430 (3691923) 3691923..3692045 - 123 Protein_3601 metal-dependent hydrolase -
PS051_RS18435 (3692061) 3692061..3692660 - 600 WP_072249376.1 peptide chain release factor H -
PS051_RS18440 (3692673) 3692673..3693125 - 453 WP_072243685.1 GNAT family N-acetyltransferase -
PS051_RS18445 (3693135) 3693135..3693533 - 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PS051_RS18450 (3693536) 3693536..3693829 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PS051_RS18455 (3693881) 3693881..3694936 - 1056 WP_059217800.1 DNA polymerase IV -
PS051_RS18460 (3695066) 3695066..3695971 - 906 WP_025237542.1 putative lateral flagellar export/assembly protein LafU -
PS051_RS18465 (3695974) 3695974..3696837 - 864 WP_001169515.1 flagellar motor stator protein MotA -
PS051_RS18470 (3696850) 3696850..3697566 - 717 WP_273781306.1 FliA/WhiG family RNA polymerase sigma factor -
PS051_RS18475 (3697587) 3697587..3698051 - 465 WP_059278868.1 flagellar basal body-associated FliL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T271578 WP_001263500.1 NZ_CP117590:c3693533-3693135 [Escherichia albertii]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT271578 WP_000554758.1 NZ_CP117590:c3693829-3693536 [Escherichia albertii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References