Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 229847..230559 Replicon chromosome
Accession NZ_CP117590
Organism Escherichia albertii strain BIA_36

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS051_RS01030 Protein ID WP_273781541.1
Coordinates 230257..230559 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS051_RS01025 Protein ID WP_000806446.1
Coordinates 229847..230185 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS051_RS01000 (224904) 224904..226886 + 1983 WP_273781540.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS051_RS01005 (226935) 226935..227963 + 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS051_RS01010 (228035) 228035..228565 - 531 WP_059220985.1 LuxR C-terminal-related transcriptional regulator -
PS051_RS01015 (228712) 228712..229278 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS051_RS01020 (229611) 229611..229790 - 180 WP_002460167.1 hypothetical protein -
PS051_RS01025 (229847) 229847..230185 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS051_RS01030 (230257) 230257..230559 - 303 WP_273781541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS051_RS01035 (230723) 230723..231217 + 495 WP_273781542.1 hypothetical protein -
PS051_RS01040 (231293) 231293..231376 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS051_RS01045 (231430) 231430..232782 - 1353 WP_273781543.1 glutathione-disulfide reductase -
PS051_RS01050 (232854) 232854..233696 - 843 WP_113650511.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11827.58 Da        Isoelectric Point: 10.0443

>T271563 WP_273781541.1 NZ_CP117590:c230559-230257 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLAPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271563 WP_000806446.1 NZ_CP117590:c230185-229847 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References