Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2522800..2523362 Replicon chromosome
Accession NZ_CP117586
Organism Escherichia albertii strain BIA_40

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag PS042_RS12625 Protein ID WP_000605679.1
Coordinates 2522800..2523078 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS042_RS12630 Protein ID WP_000781369.1
Coordinates 2523078..2523362 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS042_RS12605 (2518780) 2518780..2519211 - 432 WP_059225291.1 peroxiredoxin OsmC -
PS042_RS12610 (2519478) 2519478..2519615 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS042_RS12615 (2519772) 2519772..2521469 + 1698 WP_000433442.1 malate dehydrogenase -
PS042_RS12620 (2521604) 2521604..2522614 + 1011 WP_000642386.1 alcohol dehydrogenase AdhP -
PS042_RS12625 (2522800) 2522800..2523078 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS042_RS12630 (2523078) 2523078..2523362 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
PS042_RS12635 (2523590) 2523590..2524243 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS042_RS12640 (2524236) 2524236..2525120 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS042_RS12645 (2525133) 2525133..2528180 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T271550 WP_000605679.1 NZ_CP117586:2522800-2523078 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT271550 WP_000781369.1 NZ_CP117586:2523078-2523362 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure

References