Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 594333..595132 Replicon chromosome
Accession NZ_CP117586
Organism Escherichia albertii strain BIA_40

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag PS042_RS02925 Protein ID WP_059235443.1
Coordinates 594333..594797 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS042_RS02930 Protein ID WP_001296435.1
Coordinates 594797..595132 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS042_RS02895 (589334) 589334..589768 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PS042_RS02900 (589786) 589786..590664 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS042_RS02905 (590654) 590654..591433 - 780 WP_105175636.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS042_RS02910 (591444) 591444..591917 - 474 WP_059218168.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS042_RS02915 (591940) 591940..593220 - 1281 WP_059235447.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS042_RS02920 (593469) 593469..594278 + 810 WP_059235445.1 aga operon transcriptional regulator AgaR -
PS042_RS02925 (594333) 594333..594797 - 465 WP_059235443.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS042_RS02930 (594797) 594797..595132 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS042_RS02935 (595281) 595281..596852 - 1572 WP_059235441.1 galactarate dehydratase -
PS042_RS02940 (597223) 597223..598557 + 1335 WP_059241781.1 galactarate/glucarate/glycerate transporter GarP -
PS042_RS02945 (598573) 598573..599343 + 771 WP_059235438.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17825.22 Da        Isoelectric Point: 9.6804

>T271540 WP_059235443.1 NZ_CP117586:c594797-594333 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSSAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271540 WP_001296435.1 NZ_CP117586:c595132-594797 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References