Detailed information of TA system TA271528

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2734107..2734364
• Replicon: chromosome
• Accession: NZ_CP117583
• Organism: Escherichia albertii strain BIA_41

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: PS045_RS13325
• Protein ID: WP_001135738.1
• Coordinates: 2734107..2734259 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2734310..2734364 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PS045_RS13295	2729493..2730152	+	660	WP_000747625.1	OmpA family lipoprotein	-
PS045_RS13300	2730256..2731230	+	975	WP_000804993.1	glyoxylate/hydroxypyruvate reductase GhrB	-
PS045_RS13305	2731283..2731993	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
PS045_RS13310	2732416..2732706	+	291	WP_000455794.1	HTH-type transcriptional regulator	-
PS045_RS13315	2732989..2733201	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
PS045_RS13320	2733269..2733955	-	687	WP_059271833.1	hypothetical protein	-
PS045_RS13325	2734107..2734259	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2734310..2734364	+	55	-	-	Antitoxin
PS045_RS13330	2734580..2736649	-	2070	WP_059221279.1	glycine--tRNA ligase subunit beta	-
PS045_RS13335	2736659..2737570	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
PS045_RS13340	2737666..2737965	-	300	WP_059229187.1	YsaB family lipoprotein	-
PS045_RS13345	2738138..2739133	+	996	WP_256879259.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T271528 WP_001135738.1 NZ_CP117583:c2734259-2734107 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 55 bp

>AT271528 NZ_CP117583:2734310-2734364 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin