Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2651673..2652373 Replicon chromosome
Accession NZ_CP117583
Organism Escherichia albertii strain BIA_41

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS045_RS12965 Protein ID WP_256879206.1
Coordinates 2651673..2651963 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS045_RS12970 Protein ID WP_000806446.1
Coordinates 2652035..2652373 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS045_RS12940 (2648323) 2648323..2649165 + 843 WP_010326142.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS045_RS12945 (2649237) 2649237..2650589 + 1353 WP_054410173.1 glutathione-disulfide reductase -
PS045_RS12950 (2650643) 2650643..2650726 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS045_RS12955 (2650754) 2650754..2650927 + 174 WP_000553433.1 hypothetical protein -
PS045_RS12960 (2651017) 2651017..2651496 - 480 WP_059215194.1 hypothetical protein -
PS045_RS12965 (2651673) 2651673..2651963 + 291 WP_256879206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS045_RS12970 (2652035) 2652035..2652373 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS045_RS12975 (2652464) 2652464..2652613 + 150 WP_233991781.1 hypothetical protein -
PS045_RS12980 (2652960) 2652960..2653526 + 567 WP_059216822.1 outer membrane lipoprotein Slp -
PS045_RS12985 (2653673) 2653673..2654203 + 531 WP_256879204.1 LuxR C-terminal-related transcriptional regulator -
PS045_RS12990 (2654275) 2654275..2655303 - 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS045_RS12995 (2655352) 2655352..2657334 - 1983 WP_059251954.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11429.03 Da        Isoelectric Point: 8.8483

>T271527 WP_256879206.1 NZ_CP117583:2651673-2651963 [Escherichia albertii]
INIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNCYSSIRVNNQYRLIFK
WVNGKAEDLYLDPHKY

Download         Length: 291 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271527 WP_000806446.1 NZ_CP117583:2652035-2652373 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References