Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2296756..2297555 Replicon chromosome
Accession NZ_CP117583
Organism Escherichia albertii strain BIA_41

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9C2I0
Locus tag PS045_RS11100 Protein ID WP_059227548.1
Coordinates 2297091..2297555 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS045_RS11095 Protein ID WP_001296435.1
Coordinates 2296756..2297091 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS045_RS11080 (2292545) 2292545..2293315 - 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -
PS045_RS11085 (2293331) 2293331..2294665 - 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
PS045_RS11090 (2295036) 2295036..2296607 + 1572 WP_256878808.1 galactarate dehydratase -
PS045_RS11095 (2296756) 2296756..2297091 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS045_RS11100 (2297091) 2297091..2297555 + 465 WP_059227548.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS045_RS11105 (2297610) 2297610..2298419 - 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
PS045_RS11110 (2298668) 2298668..2299948 + 1281 WP_256878807.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS045_RS11115 (2299971) 2299971..2300444 + 474 WP_002461030.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS045_RS11120 (2300455) 2300455..2301234 + 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS045_RS11125 (2301224) 2301224..2302102 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS045_RS11130 (2302120) 2302120..2302554 + 435 WP_149451364.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17819.26 Da        Isoelectric Point: 9.7301

>T271525 WP_059227548.1 NZ_CP117583:2297091-2297555 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271525 WP_001296435.1 NZ_CP117583:2296756-2297091 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References