Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2255302..2256029 Replicon chromosome
Accession NZ_CP117583
Organism Escherichia albertii strain BIA_41

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PS045_RS10900 Protein ID WP_000550189.1
Coordinates 2255715..2256029 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS045_RS10895 Protein ID WP_256878813.1
Coordinates 2255302..2255718 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS045_RS10885 (2250395) 2250395..2252746 + 2352 WP_000695424.1 alpha-glucosidase -
PS045_RS10890 (2253194) 2253194..2255212 + 2019 WP_256878814.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PS045_RS10895 (2255302) 2255302..2255718 - 417 WP_256878813.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PS045_RS10900 (2255715) 2255715..2256029 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PS045_RS10905 (2256312) 2256312..2257448 - 1137 WP_060877474.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PS045_RS10910 (2257533) 2257533..2258036 + 504 WP_001295542.1 M48 family metallopeptidase -
PS045_RS10915 (2258113) 2258113..2258805 + 693 WP_000942533.1 vancomycin high temperature exclusion protein -
PS045_RS10920 (2258884) 2258884..2259870 + 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T271524 WP_000550189.1 NZ_CP117583:c2256029-2255715 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14983.36 Da        Isoelectric Point: 4.3697

>AT271524 WP_256878813.1 NZ_CP117583:c2255718-2255302 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMSGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References