Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1813776..1814503 Replicon chromosome
Accession NZ_CP117583
Organism Escherichia albertii strain BIA_41

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag PS045_RS08855 Protein ID WP_000547563.1
Coordinates 1814192..1814503 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS045_RS08850 Protein ID WP_000126297.1
Coordinates 1813776..1814195 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS045_RS08835 (1809895) 1809895..1812147 - 2253 WP_256878885.1 carbamoyltransferase HypF -
PS045_RS08840 (1812300) 1812300..1812827 - 528 WP_001078780.1 electron transport protein HydN -
PS045_RS08845 (1813256) 1813256..1813684 + 429 WP_000536064.1 hypothetical protein -
PS045_RS08850 (1813776) 1813776..1814195 - 420 WP_000126297.1 helix-turn-helix domain-containing protein Antitoxin
PS045_RS08855 (1814192) 1814192..1814503 - 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
PS045_RS08860 (1814665) 1814665..1815420 - 756 WP_125060797.1 hypothetical protein -
PS045_RS08865 (1815463) 1815463..1815933 - 471 WP_059219259.1 hydrogenase maturation peptidase HycI -
PS045_RS08870 (1815926) 1815926..1816336 - 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
PS045_RS08875 (1816333) 1816333..1817100 - 768 WP_059214453.1 formate hydrogenlyase subunit HycG -
PS045_RS08880 (1817100) 1817100..1817642 - 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
PS045_RS08885 (1817652) 1817652..1819361 - 1710 WP_256921794.1 formate hydrogenlyase subunit HycE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T271521 WP_000547563.1 NZ_CP117583:c1814503-1814192 [Escherichia albertii]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15446.45 Da        Isoelectric Point: 4.4596

>AT271521 WP_000126297.1 NZ_CP117583:c1814195-1813776 [Escherichia albertii]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References