Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 560710..561272 Replicon chromosome
Accession NZ_CP117583
Organism Escherichia albertii strain BIA_41

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag PS045_RS02705 Protein ID WP_000605679.1
Coordinates 560994..561272 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS045_RS02700 Protein ID WP_000781369.1
Coordinates 560710..560994 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS045_RS02680 (557915) 557915..558799 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS045_RS02685 (558792) 558792..559445 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS045_RS02690 (559641) 559641..560099 + 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -
PS045_RS02695 (560229) 560229..560705 + 477 WP_059225294.1 NUDIX domain-containing protein -
PS045_RS02700 (560710) 560710..560994 - 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
PS045_RS02705 (560994) 560994..561272 - 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS045_RS02710 (561458) 561458..562468 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS045_RS02715 (562603) 562603..564300 - 1698 WP_000433442.1 malate dehydrogenase -
PS045_RS02720 (564457) 564457..564594 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS045_RS02725 (564861) 564861..565292 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 559641..560099 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T271514 WP_000605679.1 NZ_CP117583:c561272-560994 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT271514 WP_000781369.1 NZ_CP117583:c560994-560710 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure

References