Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-sib/SymE(toxin)
Location 3877083..3877495 Replicon chromosome
Accession NZ_CP117580
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name symE Uniprot ID A0A7U8ZC55
Locus tag PS044_RS18910 Protein ID WP_025237738.1
Coordinates 3877154..3877495 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name sib
Locus tag -
Coordinates 3877083..3877159 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS18900 (3873978) 3873978..3875567 + 1590 WP_273807938.1 type I restriction-modification system methyltransferase -
PS044_RS18905 (3875564) 3875564..3876926 + 1363 Protein_3693 restriction endonuclease subunit S -
- (3877083) 3877083..3877159 - 77 NuclAT_7 - Antitoxin
- (3877083) 3877083..3877159 - 77 NuclAT_7 - Antitoxin
- (3877083) 3877083..3877159 - 77 NuclAT_7 - Antitoxin
- (3877083) 3877083..3877159 - 77 NuclAT_7 - Antitoxin
- (3877083) 3877083..3877159 - 77 NuclAT_8 - Antitoxin
- (3877083) 3877083..3877159 - 77 NuclAT_8 - Antitoxin
- (3877083) 3877083..3877159 - 77 NuclAT_8 - Antitoxin
- (3877083) 3877083..3877159 - 77 NuclAT_8 - Antitoxin
PS044_RS18910 (3877154) 3877154..3877495 + 342 WP_025237738.1 endoribonuclease SymE Toxin
PS044_RS18915 (3877542) 3877542..3878708 - 1167 WP_077696034.1 DUF1524 domain-containing protein -
PS044_RS18920 (3878747) 3878747..3879638 - 892 Protein_3696 DUF262 domain-containing protein -
PS044_RS18925 (3879863) 3879863..3880036 + 174 Protein_3697 GntR family transcriptional regulator -
PS044_RS18930 (3880188) 3880188..3881119 - 932 Protein_3698 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3876570..3887413 10843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12310.12 Da        Isoelectric Point: 7.8219

>T271508 WP_025237738.1 NZ_CP117580:3877154-3877495 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT271508 NZ_CP117580:c3877159-3877083 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZC55

Antitoxin

Download structure file

References