Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1131325..1132052 Replicon chromosome
Accession NZ_CP117580
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag PS044_RS05465 Protein ID WP_000547563.1
Coordinates 1131325..1131636 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS044_RS05470 Protein ID WP_000126297.1
Coordinates 1131633..1132052 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS05435 (1126467) 1126467..1128176 + 1710 WP_025238503.1 formate hydrogenlyase subunit HycE -
PS044_RS05440 (1128186) 1128186..1128728 + 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
PS044_RS05445 (1128728) 1128728..1129495 + 768 WP_025238504.1 formate hydrogenlyase subunit HycG -
PS044_RS05450 (1129492) 1129492..1129902 + 411 WP_001291913.1 formate hydrogenlyase assembly protein HycH -
PS044_RS05455 (1129895) 1129895..1130365 + 471 WP_000132954.1 hydrogenase maturation peptidase HycI -
PS044_RS05460 (1130408) 1130408..1131163 + 756 WP_025238505.1 hypothetical protein -
PS044_RS05465 (1131325) 1131325..1131636 + 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
PS044_RS05470 (1131633) 1131633..1132052 + 420 WP_000126297.1 helix-turn-helix domain-containing protein Antitoxin
PS044_RS05475 (1132144) 1132144..1132572 - 429 WP_000536065.1 DUF4259 domain-containing protein -
PS044_RS05480 (1132995) 1132995..1133522 + 528 WP_273808284.1 electron transport protein HydN -
PS044_RS05485 (1133675) 1133675..1135927 + 2253 WP_025238507.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T271499 WP_000547563.1 NZ_CP117580:1131325-1131636 [Escherichia albertii]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15446.45 Da        Isoelectric Point: 4.4596

>AT271499 WP_000126297.1 NZ_CP117580:1131633-1132052 [Escherichia albertii]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References