Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 270592..271304 Replicon chromosome
Accession NZ_CP117580
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS044_RS01245 Protein ID WP_000162413.1
Coordinates 271002..271304 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS044_RS01240 Protein ID WP_000806446.1
Coordinates 270592..270930 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS01215 (265633) 265633..267614 + 1982 Protein_239 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS044_RS01220 (267663) 267663..268691 + 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS044_RS01225 (268763) 268763..269293 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS044_RS01230 (269440) 269440..270006 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS044_RS01235 (270368) 270368..270535 - 168 WP_232529606.1 hypothetical protein -
PS044_RS01240 (270592) 270592..270930 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS044_RS01245 (271002) 271002..271304 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS044_RS01250 (271468) 271468..271947 + 480 WP_025238141.1 hypothetical protein -
PS044_RS01255 (272037) 272037..272210 - 174 WP_000553433.1 hypothetical protein -
PS044_RS01260 (272238) 272238..272321 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS044_RS01265 (272375) 272375..273727 - 1353 WP_256876822.1 glutathione-disulfide reductase -
PS044_RS01270 (273799) 273799..274641 - 843 WP_025238143.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271495 WP_000162413.1 NZ_CP117580:c271304-271002 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271495 WP_000806446.1 NZ_CP117580:c270930-270592 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References