Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2687248..2687960 Replicon chromosome
Accession NZ_CP117575
Organism Escherichia albertii strain BIA_5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS037_RS13115 Protein ID WP_273821100.1
Coordinates 2687248..2687550 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS037_RS13120 Protein ID WP_000806447.1
Coordinates 2687622..2687960 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS037_RS13090 (2683911) 2683911..2684753 + 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS037_RS13095 (2684825) 2684825..2686177 + 1353 WP_000160823.1 glutathione-disulfide reductase -
PS037_RS13100 (2686231) 2686231..2686314 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS037_RS13105 (2686342) 2686342..2686515 + 174 WP_273821098.1 hypothetical protein -
PS037_RS13110 (2686605) 2686605..2687084 - 480 WP_273821099.1 hypothetical protein -
PS037_RS13115 (2687248) 2687248..2687550 + 303 WP_273821100.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS037_RS13120 (2687622) 2687622..2687960 + 339 WP_000806447.1 HigA family addiction module antitoxin Antitoxin
PS037_RS13125 (2688017) 2688017..2688184 + 168 WP_232529606.1 hypothetical protein -
PS037_RS13130 (2688546) 2688546..2689112 + 567 WP_273821101.1 outer membrane lipoprotein Slp -
PS037_RS13135 (2689259) 2689259..2689789 + 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS037_RS13140 (2689861) 2689861..2690889 - 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS037_RS13145 (2690938) 2690938..2692920 - 1983 WP_000089601.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11888.63 Da        Isoelectric Point: 10.0443

>T271482 WP_273821100.1 NZ_CP117575:2687248-2687550 [Escherichia albertii]
MTKKINIKNFRDAWLDDFFEFSTPHKKMPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13010.90 Da        Isoelectric Point: 5.2075

>AT271482 WP_000806447.1 NZ_CP117575:2687622-2687960 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNSRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References