Detailed information of TA system TA271480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 2339887..2340686
• Replicon: chromosome
• Accession: NZ_CP117575
• Organism: Escherichia albertii strain BIA_5

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: A0A8H9C2I0
• Locus tag: PS037_RS11270
• Protein ID: WP_059227548.1
• Coordinates: 2340222..2340686 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: S1PPV5
• Locus tag: PS037_RS11265
• Protein ID: WP_001296435.1
• Coordinates: 2339887..2340222 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PS037_RS11250 (2335677)	2335677..2336447	-	771	WP_001063508.1	2-dehydro-3-deoxyglucarate aldolase	-
PS037_RS11255 (2336463)	2336463..2337797	-	1335	WP_273821864.1	galactarate/glucarate/glycerate transporter GarP	-
PS037_RS11260 (2338167)	2338167..2339738	+	1572	WP_059256163.1	galactarate dehydratase	-
PS037_RS11265 (2339887)	2339887..2340222	+	336	WP_001296435.1	type II toxin-antitoxin system antitoxin PrlF	Antitoxin
PS037_RS11270 (2340222)	2340222..2340686	+	465	WP_059227548.1	type II toxin-antitoxin system ribonuclease toxin YhaV	Toxin
PS037_RS11275 (2340741)	2340741..2341550	-	810	WP_000072169.1	aga operon transcriptional regulator AgaR	-
PS037_RS11280 (2341799)	2341799..2343079	+	1281	WP_059216469.1	tagatose-bisphosphate aldolase subunit KbaZ	-
PS037_RS11285 (2343102)	2343102..2343575	+	474	WP_002461030.1	PTS N-acetylgalactosamine transporter subunit IIB	-
PS037_RS11290 (2343586)	2343586..2344365	+	780	WP_141109251.1	PTS N-acetylgalactosamine transporter subunit IIC	-
PS037_RS11295 (2344355)	2344355..2345233	+	879	WP_059256166.1	PTS N-acetylgalactosamine transporter subunit IID	-
PS037_RS11300 (2345251)	2345251..2345685	+	435	WP_000948821.1	PTS galactosamine/N-acetylgalactosamine transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17819.26 Da
• Isoelectric Point: 9.7301

>T271480 WP_059227548.1 NZ_CP117575:2340222-2340686 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Nucleotide

• Length: 465 bp

>T271480 NZ_CP117575:2340222-2340686 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTTTCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACAGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12321.92 Da
• Isoelectric Point: 4.5392

>AT271480 WP_001296435.1 NZ_CP117575:2339887-2340222 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Nucleotide

• Length: 336 bp

>AT271480 NZ_CP117575:2339887-2340222 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: S1PPV5