Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2346720..2347282 Replicon chromosome
Accession NZ_CP117570
Organism Escherichia albertii strain BIA_50

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS035_RS11290 Protein ID WP_273817968.1
Coordinates 2346720..2346998 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS035_RS11295 Protein ID WP_000781370.1
Coordinates 2346998..2347282 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS035_RS11270 (2342709) 2342709..2343140 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS035_RS11275 (2343398) 2343398..2343535 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS035_RS11280 (2343692) 2343692..2345389 + 1698 WP_000433442.1 malate dehydrogenase -
PS035_RS11285 (2345524) 2345524..2346534 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS035_RS11290 (2346720) 2346720..2346998 + 279 WP_273817968.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS035_RS11295 (2346998) 2346998..2347282 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS035_RS11300 (2347509) 2347509..2348162 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS035_RS11305 (2348155) 2348155..2349039 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS035_RS11310 (2349052) 2349052..2352099 - 3048 WP_273817969.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10563.12 Da        Isoelectric Point: 7.3995

>T271456 WP_273817968.1 NZ_CP117570:2346720-2346998 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSSDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271456 WP_000781370.1 NZ_CP117570:2346998-2347282 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References