Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2299202..2300001 Replicon chromosome
Accession NZ_CP117568
Organism Escherichia albertii strain BIA_5-2

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9C2I0
Locus tag PS053_RS11110 Protein ID WP_059227548.1
Coordinates 2299537..2300001 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS053_RS11105 Protein ID WP_001296435.1
Coordinates 2299202..2299537 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS053_RS11090 (2294991) 2294991..2295761 - 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -
PS053_RS11095 (2295777) 2295777..2297111 - 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
PS053_RS11100 (2297482) 2297482..2299053 + 1572 WP_256878808.1 galactarate dehydratase -
PS053_RS11105 (2299202) 2299202..2299537 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS053_RS11110 (2299537) 2299537..2300001 + 465 WP_059227548.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS053_RS11115 (2300056) 2300056..2300865 - 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
PS053_RS11120 (2301114) 2301114..2302394 + 1281 WP_256878807.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS053_RS11125 (2302417) 2302417..2302890 + 474 WP_002461030.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS053_RS11130 (2302901) 2302901..2303680 + 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS053_RS11135 (2303670) 2303670..2304548 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS053_RS11140 (2304566) 2304566..2305000 + 435 WP_149451364.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17819.26 Da        Isoelectric Point: 9.7301

>T271435 WP_059227548.1 NZ_CP117568:2299537-2300001 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271435 WP_001296435.1 NZ_CP117568:2299202-2299537 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References