Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2257748..2258475 Replicon chromosome
Accession NZ_CP117568
Organism Escherichia albertii strain BIA_5-2

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PS053_RS10910 Protein ID WP_000550189.1
Coordinates 2258161..2258475 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS053_RS10905 Protein ID WP_256878813.1
Coordinates 2257748..2258164 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS053_RS10895 (2252841) 2252841..2255192 + 2352 WP_000695424.1 alpha-glucosidase -
PS053_RS10900 (2255640) 2255640..2257658 + 2019 WP_256878814.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PS053_RS10905 (2257748) 2257748..2258164 - 417 WP_256878813.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PS053_RS10910 (2258161) 2258161..2258475 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PS053_RS10915 (2258758) 2258758..2259894 - 1137 WP_060877474.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PS053_RS10920 (2259979) 2259979..2260482 + 504 WP_001295542.1 M48 family metallopeptidase -
PS053_RS10925 (2260559) 2260559..2261251 + 693 WP_000942533.1 vancomycin high temperature exclusion protein -
PS053_RS10930 (2261330) 2261330..2262316 + 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T271434 WP_000550189.1 NZ_CP117568:c2258475-2258161 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14983.36 Da        Isoelectric Point: 4.3697

>AT271434 WP_256878813.1 NZ_CP117568:c2258164-2257748 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMSGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References