Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1816222..1816949 Replicon chromosome
Accession NZ_CP117568
Organism Escherichia albertii strain BIA_5-2

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag PS053_RS08865 Protein ID WP_000547563.1
Coordinates 1816638..1816949 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS053_RS08860 Protein ID WP_000126297.1
Coordinates 1816222..1816641 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS053_RS08845 (1812341) 1812341..1814593 - 2253 WP_256878885.1 carbamoyltransferase HypF -
PS053_RS08850 (1814746) 1814746..1815273 - 528 WP_001078780.1 electron transport protein HydN -
PS053_RS08855 (1815702) 1815702..1816130 + 429 WP_000536064.1 hypothetical protein -
PS053_RS08860 (1816222) 1816222..1816641 - 420 WP_000126297.1 helix-turn-helix domain-containing protein Antitoxin
PS053_RS08865 (1816638) 1816638..1816949 - 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
PS053_RS08870 (1817111) 1817111..1817866 - 756 WP_125060797.1 hypothetical protein -
PS053_RS08875 (1817909) 1817909..1818379 - 471 WP_059219259.1 hydrogenase maturation peptidase HycI -
PS053_RS08880 (1818372) 1818372..1818782 - 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
PS053_RS08885 (1818779) 1818779..1819546 - 768 WP_059214453.1 formate hydrogenlyase subunit HycG -
PS053_RS08890 (1819546) 1819546..1820088 - 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
PS053_RS08895 (1820098) 1820098..1821807 - 1710 WP_256921794.1 formate hydrogenlyase subunit HycE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T271431 WP_000547563.1 NZ_CP117568:c1816949-1816638 [Escherichia albertii]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15446.45 Da        Isoelectric Point: 4.4596

>AT271431 WP_000126297.1 NZ_CP117568:c1816641-1816222 [Escherichia albertii]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References