Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3754859..3755421 Replicon chromosome
Accession NZ_CP117562
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS049_RS18520 Protein ID WP_149507449.1
Coordinates 3754859..3755137 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag PS049_RS18525 Protein ID WP_021528209.1
Coordinates 3755137..3755421 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS18500 (3750839) 3750839..3751270 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS049_RS18505 (3751537) 3751537..3751674 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS049_RS18510 (3751831) 3751831..3753528 + 1698 WP_000433442.1 malate dehydrogenase -
PS049_RS18515 (3753663) 3753663..3754673 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS049_RS18520 (3754859) 3754859..3755137 + 279 WP_149507449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS049_RS18525 (3755137) 3755137..3755421 + 285 WP_021528209.1 HigA family addiction module antitoxin Antitoxin
PS049_RS18530 (3755649) 3755649..3756302 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS049_RS18535 (3756295) 3756295..3757179 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS049_RS18540 (3757192) 3757192..3760239 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10520.12 Da        Isoelectric Point: 8.0733

>T271409 WP_149507449.1 NZ_CP117562:3754859-3755137 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GNAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT271409 WP_021528209.1 NZ_CP117562:3755137-3755421 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References