Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1835529..1836256 Replicon chromosome
Accession NZ_CP117562
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PS049_RS08920 Protein ID WP_000550189.1
Coordinates 1835529..1835843 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS049_RS08925 Protein ID WP_000560272.1
Coordinates 1835840..1836256 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS08900 (1831688) 1831688..1832674 - 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -
PS049_RS08905 (1832753) 1832753..1833445 - 693 WP_000942533.1 vancomycin high temperature exclusion protein -
PS049_RS08910 (1833522) 1833522..1834025 - 504 WP_131109781.1 M48 family metallopeptidase -
PS049_RS08915 (1834110) 1834110..1835246 + 1137 WP_273782898.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PS049_RS08920 (1835529) 1835529..1835843 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PS049_RS08925 (1835840) 1835840..1836256 + 417 WP_000560272.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PS049_RS08930 (1836346) 1836346..1838364 - 2019 WP_273782900.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PS049_RS08935 (1838706) 1838706..1841057 - 2352 WP_273820204.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T271400 WP_000550189.1 NZ_CP117562:1835529-1835843 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14993.40 Da        Isoelectric Point: 4.3697

>AT271400 WP_000560272.1 NZ_CP117562:1835840-1836256 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References