Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1793943..1794742 Replicon chromosome
Accession NZ_CP117562
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag PS049_RS08715 Protein ID WP_059271009.1
Coordinates 1793943..1794407 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS049_RS08720 Protein ID WP_001296435.1
Coordinates 1794407..1794742 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS08685 (1789005) 1789005..1789439 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PS049_RS08690 (1789457) 1789457..1790335 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS049_RS08695 (1790325) 1790325..1791104 - 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS049_RS08700 (1791115) 1791115..1791588 - 474 WP_059218168.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS049_RS08705 (1791611) 1791611..1792812 - 1202 Protein_1686 tagatose-bisphosphate aldolase subunit KbaZ -
PS049_RS08710 (1793079) 1793079..1793888 + 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
PS049_RS08715 (1793943) 1793943..1794407 - 465 WP_059271009.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS049_RS08720 (1794407) 1794407..1794742 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS049_RS08725 (1794891) 1794891..1796462 - 1572 WP_273820197.1 galactarate dehydratase -
PS049_RS08730 (1796833) 1796833..1798167 + 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
PS049_RS08735 (1798183) 1798183..1798953 + 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17835.26 Da        Isoelectric Point: 9.6804

>T271399 WP_059271009.1 NZ_CP117562:c1794407-1793943 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271399 WP_001296435.1 NZ_CP117562:c1794742-1794407 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References