Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1440305..1441017 Replicon chromosome
Accession NZ_CP117562
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS049_RS06865 Protein ID WP_000162413.1
Coordinates 1440715..1441017 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS049_RS06860 Protein ID WP_000806446.1
Coordinates 1440305..1440643 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS06835 (1435360) 1435360..1437342 + 1983 WP_107193138.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS049_RS06840 (1437391) 1437391..1438419 + 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS049_RS06845 (1438491) 1438491..1439021 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS049_RS06850 (1439168) 1439168..1439734 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS049_RS06855 (1440081) 1440081..1440248 - 168 WP_273782721.1 hypothetical protein -
PS049_RS06860 (1440305) 1440305..1440643 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS049_RS06865 (1440715) 1440715..1441017 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS049_RS06870 (1441181) 1441181..1441660 + 480 WP_273782723.1 hypothetical protein -
PS049_RS06875 (1441750) 1441750..1441923 - 174 WP_000553433.1 hypothetical protein -
PS049_RS06880 (1441951) 1441951..1442034 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS049_RS06885 (1442088) 1442088..1443440 - 1353 WP_273782725.1 glutathione-disulfide reductase -
PS049_RS06890 (1443512) 1443512..1444354 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271397 WP_000162413.1 NZ_CP117562:c1441017-1440715 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271397 WP_000806446.1 NZ_CP117562:c1440643-1440305 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References