Detailed information of TA system TA271377

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-OrzO/SymE(toxin)
• Location: 4019560..4019972
• Replicon: chromosome
• Accession: NZ_CP117558
• Organism: Escherichia albertii strain BIA_8

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8D9PK47
• Locus tag: PS052_RS19890
• Protein ID: WP_000132619.1
• Coordinates: 4019631..4019972 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	OrzO
Locus tag	-
Coordinates	4019560..4019636 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PS052_RS19870 (4015422)	4015422..4015913	+	492	Protein_3889	type I restriction-modification system subunit M N-terminal domain-containing protein	-
PS052_RS19875 (4015969)	4015969..4016666	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
PS052_RS19880 (4016682)	4016682..4017668	+	987	Protein_3891	N-6 DNA methylase	-
PS052_RS19885 (4017668)	4017668..4019410	+	1743	WP_103054261.1	restriction endonuclease subunit S	-
- (4019560)	4019560..4019636	-	77	NuclAT_8	-	Antitoxin
- (4019560)	4019560..4019636	-	77	NuclAT_8	-	Antitoxin
- (4019560)	4019560..4019636	-	77	NuclAT_8	-	Antitoxin
- (4019560)	4019560..4019636	-	77	NuclAT_8	-	Antitoxin
- (4019560)	4019560..4019636	-	77	NuclAT_9	-	Antitoxin
- (4019560)	4019560..4019636	-	77	NuclAT_9	-	Antitoxin
- (4019560)	4019560..4019636	-	77	NuclAT_9	-	Antitoxin
- (4019560)	4019560..4019636	-	77	NuclAT_9	-	Antitoxin
PS052_RS19890 (4019631)	4019631..4019972	+	342	WP_000132619.1	endoribonuclease SymE	Toxin
PS052_RS19895 (4020134)	4020134..4021512	+	1379	Protein_3894	5-methylcytosine-specific restriction endonuclease subunit McrB	-
PS052_RS19900 (4021512)	4021512..4022558	+	1047	WP_072252312.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
PS052_RS19905 (4022614)	4022614..4023692	-	1079	Protein_3896	DUF1998 domain-containing protein	-
PS052_RS19910 (4024007)	4024007..4024938	-	932	Protein_3897	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4011814..4035965	24151

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12322.13 Da
• Isoelectric Point: 7.8219

>T271377 WP_000132619.1 NZ_CP117558:4019631-4019972 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

Antitoxin

Nucleotide

• Length: 77 bp

>AT271377 NZ_CP117558:c4019636-4019560 [Escherichia albertii]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin