Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2330260..2330822 Replicon chromosome
Accession NZ_CP117558
Organism Escherichia albertii strain BIA_8

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag PS052_RS11440 Protein ID WP_000605676.1
Coordinates 2330260..2330538 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag PS052_RS11445 Protein ID WP_021528209.1
Coordinates 2330538..2330822 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS052_RS11420 (2326249) 2326249..2326680 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS052_RS11425 (2326938) 2326938..2327075 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS052_RS11430 (2327232) 2327232..2328929 + 1698 WP_273765612.1 malate dehydrogenase -
PS052_RS11435 (2329064) 2329064..2330074 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS052_RS11440 (2330260) 2330260..2330538 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS052_RS11445 (2330538) 2330538..2330822 + 285 WP_021528209.1 HigA family addiction module antitoxin Antitoxin
PS052_RS11450 (2331050) 2331050..2331703 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS052_RS11455 (2331696) 2331696..2332580 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS052_RS11460 (2332593) 2332593..2335640 - 3048 WP_158649888.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T271372 WP_000605676.1 NZ_CP117558:2330260-2330538 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT271372 WP_021528209.1 NZ_CP117558:2330538-2330822 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure

References