Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1030440..1030685 Replicon chromosome
Accession NZ_CP117558
Organism Escherichia albertii strain BIA_8

Toxin (Protein)


Gene name hokX Uniprot ID L4J2K8
Locus tag PS052_RS04995 Protein ID WP_000956460.1
Coordinates 1030533..1030685 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1030440..1030488 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS052_RS04980 1025939..1027738 + 1800 WP_103053841.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
PS052_RS04985 1027738..1029450 + 1713 WP_103053840.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
PS052_RS04990 1029535..1030269 + 735 WP_059228192.1 phosphoadenosine phosphosulfate reductase -
- 1030440..1030488 - 49 - - Antitoxin
PS052_RS04995 1030533..1030685 + 153 WP_000956460.1 Hok/Gef family protein Toxin
PS052_RS05000 1030849..1031961 - 1113 WP_059228194.1 IS4-like element IS421 family transposase -
PS052_RS05005 1032214..1034871 + 2658 WP_123057910.1 CRISPR-associated helicase Cas3' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1030849..1031961 1112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5602.81 Da        Isoelectric Point: 7.7899

>T271367 WP_000956460.1 NZ_CP117558:1030533-1030685 [Escherichia albertii]
MLTKYALVAIIVLCFTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 49 bp

>AT271367 NZ_CP117558:c1030488-1030440 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G7J5

Antitoxin

Download structure file

References