Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 618448..619175 Replicon chromosome
Accession NZ_CP117558
Organism Escherichia albertii strain BIA_8

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PS052_RS03110 Protein ID WP_000550189.1
Coordinates 618448..618762 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS052_RS03115 Protein ID WP_103053950.1
Coordinates 618759..619175 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS052_RS03090 (614607) 614607..615593 - 987 WP_103053951.1 Gfo/Idh/MocA family oxidoreductase -
PS052_RS03095 (615672) 615672..616364 - 693 WP_025238291.1 vancomycin high temperature exclusion protein -
PS052_RS03100 (616441) 616441..616944 - 504 WP_044709508.1 M48 family metallopeptidase -
PS052_RS03105 (617029) 617029..618165 + 1137 WP_059241776.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PS052_RS03110 (618448) 618448..618762 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PS052_RS03115 (618759) 618759..619175 + 417 WP_103053950.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PS052_RS03120 (619265) 619265..621283 - 2019 WP_103053949.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PS052_RS03125 (621726) 621726..624077 - 2352 WP_000695424.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T271365 WP_000550189.1 NZ_CP117558:618448-618762 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15019.44 Da        Isoelectric Point: 4.2698

>AT271365 WP_103053950.1 NZ_CP117558:618759-619175 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDYLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References