Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 228898..229610 Replicon chromosome
Accession NZ_CP117558
Organism Escherichia albertii strain BIA_8

Toxin (Protein)


Gene name higB Uniprot ID A0A8D9ULK1
Locus tag PS052_RS01060 Protein ID WP_059257620.1
Coordinates 229308..229610 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS052_RS01055 Protein ID WP_000806446.1
Coordinates 228898..229236 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS052_RS01030 (223949) 223949..225931 + 1983 WP_103054026.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS052_RS01035 (225980) 225980..227008 + 1029 WP_103054025.1 hematinate-forming heme oxygenase ChuS -
PS052_RS01040 (227080) 227080..227610 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS052_RS01045 (227757) 227757..228323 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS052_RS01050 (228670) 228670..228807 - 138 WP_199768253.1 hypothetical protein -
PS052_RS01055 (228898) 228898..229236 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS052_RS01060 (229308) 229308..229610 - 303 WP_059257620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS052_RS01065 (229774) 229774..230253 + 480 WP_103054024.1 hypothetical protein -
PS052_RS01070 (230343) 230343..230516 - 174 WP_000553433.1 hypothetical protein -
PS052_RS01075 (230544) 230544..230627 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS052_RS01080 (230681) 230681..232033 - 1353 WP_059225142.1 glutathione-disulfide reductase -
PS052_RS01085 (232105) 232105..232947 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11843.53 Da        Isoelectric Point: 9.8664

>T271362 WP_059257620.1 NZ_CP117558:c229610-229308 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWANGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271362 WP_000806446.1 NZ_CP117558:c229236-228898 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References