Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2491451..2492013 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag PS032_RS12455 Protein ID WP_000605675.1
Coordinates 2491735..2492013 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS032_RS12450 Protein ID WP_000781370.1
Coordinates 2491451..2491735 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS12435 (2486810) 2486810..2489857 + 3048 WP_137650311.1 formate dehydrogenase-N subunit alpha -
PS032_RS12440 (2489870) 2489870..2490754 + 885 WP_137650310.1 formate dehydrogenase N subunit beta -
PS032_RS12445 (2490747) 2490747..2491400 + 654 WP_000045646.1 formate dehydrogenase-N subunit gamma -
PS032_RS12450 (2491451) 2491451..2491735 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS032_RS12455 (2491735) 2491735..2492013 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS032_RS12460 (2492199) 2492199..2493209 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS032_RS12465 (2493344) 2493344..2495041 - 1698 WP_107192708.1 malate dehydrogenase -
PS032_RS12470 (2495198) 2495198..2495335 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS032_RS12475 (2495602) 2495602..2496033 + 432 WP_137650309.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T271345 WP_000605675.1 NZ_CP117556:c2492013-2491735 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271345 WP_000781370.1 NZ_CP117556:c2491735-2491451 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References